SENNAE FOLIUM 17 - Sennoside 10
Senna
Pronunciation: (SEN-ah)Class: Laxative Trade Names:
Agoral
- Liquid 25 mg
Trade Names:
Black Draught
- Granules 20 mg/5 mL
- Tablets 6 mg
Trade Names:
ex•lax
- Tablets 15 mg
Trade Names:
ex•lax chocolate
- Tablets 15 mg
Trade Names:
Fletcher Castoria
- Liquid 33.3 mg/mL
Trade Names:
Senexon
- Tablets 8.5 mg
Trade Names:
Senna-Gen
- Tablets 8.6 mg
Trade Names:
Senokot
- Granules 15 mg/5 mL
- Syrup 8.8 mg/5 mL
- Tablets 8.6 mg
Trade Names:
SenokotXTRA
- Tablets 17 mg
Senna Laxative Pills Extra Strength Peristaltic Stimulant (Canada)
Senna Laxative Pills Regular Strength Peristaltic Stimulant (Canada)
Senna Tablets Peristaltic Stimulant (Canada)
Pharmacology
Directly acts on intestinal mucosa by altering water and electrolyte secretion, inducing peristalsis and defecation.
Indications and Usage
Short-term treatment of constipation; preoperative and preradiographic bowel evacuation for procedures involving GI tract.
Contraindications
Nausea, vomiting, or other symptoms of appendicitis; acute surgical abdomen; fecal impaction; intestinal obstruction; undiagnosed abdominal pain.
Dosage and Administration
AdultsPO 2 tablets, 5 mL of granules or 10 to 15 mL of syrup, usually at bedtime (max, 15 mL twice daily of syrup).
PR 1 suppository at bedtime; may repeat in 2 h.
Children 6 to 12 y of age PO 1 tablet or 2.5 mL granules, or 5 to 7.5 mL of syrup once daily, usually at bedtime (max, 7.5 mL twice daily of syrup).
PR ½ suppository at bedtime.
2 to younger than 6 y PO 2.5 to 3.75 mL of syrup once daily, usually at bedtime (max, 3.75 mL twice daily of syrup).
General Advice
- Administer at bedtime on empty stomach.
- Shake liquid solution before administering.
- Dissolve granules before administering.
- Give oral dosages with full glass of water or juice.
- Administer suppository with patient lying on left side.
Storage/Stability
Store between 59° and 86° F.Drug Interactions
None well documented.Adverse Reactions
Cardiovascular
Palpitations.CNS
Dizziness, fainting.GI
Abdominal cramping, bloating, excessive bowel activity (eg, griping, diarrhea, nausea, vomiting), flatulence, perianal irritation.
Miscellaneous
Sweating, weakness.Precautions
MonitorAssess bowel function, including normal frequency, type, last bowel movement, bowel sounds, abdominal distention. |
Pregnancy
Category C .Lactation
Undetermined.Abuse/dependency
Long-term use may lead to laxative dependency, which may result in fluid and electrolyte imbalances, steatorrhea, osteomalacia, and vitamin and mineral deficiencies. Cathartic colon, a poorly functioning colon, results from long-term abuse. Pathologic presentation may resemble ulcerative colitis.Discoloration of acidic urine
May result in yellow-brown urine.Discoloration of alkaline urine
May result in pink to red urine.Fluid and electrolyte imbalance
Excessive laxative use may lead to significant fluid and electrolyte imbalance.
Melanosis Coli
Darkened pigmentation of colonic mucosa may occur after long-term use, usually resolving within 5 to 11 mo of discontinuation.
Rectal bleeding or failure to respond
May indicate serious condition requiring further attention.
Overdosage
Symptoms
Gripping pain, diarrhea.Patient Information
- Explain potential hazards (eg, dependence) associated with long-term laxative use.
- Advise that senna may result in discolored yellow-brown or reddish urine.
- Explain that bowel patterns are very individual.
- Identify measures to improve bowel function (ie, fluids, activity, dietary bulk).
- Caution against taking laxatives in presence of acute abdominal pain or in presence of nausea or vomiting.
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